Police are investigating the circumstances of a fatal collision at Sugarloaf Creek, west of Tallarook, this afternoon.

Emergency services were called to the two-car collision at the intersection of Sugarloaf Creek Road and Seymour-Pyalong Road about 4.20pm.

The driver of one of the cars, believed to be a man in his 50s, died at the scene.

The other driver, a woman in her 20s, was taken to hospital with non-life-threatening injuries.

The exact circumstances surrounding the collision are yet to be determined and investigations are ongoing.

Police would like anyone who witnessed the collision or with dashcam footage to contact Crime Stoppers on 1800 333 000 or submit a confidential report via www.crimestoppersvic.com.au.